An Insight into Male Impotence and Cialis as the Drug of Choice

Erectile Dysfunction (Male Impotence)

Erectile dysfunction or male impotence is the inability to get or maintain an erection that is firm enough for intercourse. The situation, wherein a person is either unable to get an erection at all or looses erection during intercourse, is medically termed as erectile dysfunction.

Erection problems are common in adult men as almost all men at some point in their lives experience occasional difficulty getting or maintaining an erection. In most people, it is a temporary condition that goes away with little or no treatment. But, for some it may be an ongoing problem and thus require medical intervention.

If there is a difficulty in having or keeping an erection more than 25% of the time, it is considered a problem. The problem can either be psychological or physical. This can be determined by calculating the number of nighttime erections. Normally, men have 3 to 5 erections per night, each lasting up to 30 minutes. In most men, sex drive is unaffected by erection difficulties. Physical causes are more common in older men, while psychological causes are more common in younger men. In addition, erection problems have a propensity to become more common with age, yet, it affects men at any age.

An erection requires the interaction of the brain, nerves, hormones, and blood vessels. Anything that interferes with the normal physiological processes can become a problem. Common causes include:

·        Diseases and conditions such as diabetes, high blood pressure, heart or thyroid conditions, poor circulation, low testosterone, depression, spinal cord injury, nerve damage (for example, from prostate surgery), or neurologic disorders (such as multiple sclerosis or Parkinson's disease)

·        Medications such as blood pressure medications (especially beta-blockers), heart medications (such as digoxin), some peptic ulcer medications, sleeping pills, and antidepressants

·        Nicotine, alcohol, or cocaine

·        Poor partner communication

·        Stress, fear, anxiety, or anger

·        Unrealistic sexual expectations

·        "Vicious cycle" of doubt, failure, or negative communication that reinforces erection problems

Medicines for Erectile Dysfunction Treatment

The use of ED drugs is not recommended in men who have a recent history of stroke or myocardial infarction (within the last 6-8 weeks), or who have significantly low blood pressure, uncontrolled high blood pressure, unstable angina, severe cardiac failure, severe liver impairment or end-stage kidney disease requiring dialysis. But others can safely use the drug under medical supervision.

Phosphodiesterase type-5 (PDE-5) inhibitors work by enhancing the effect of nitric oxide. As a result, the penile cavernosa smooth muscle relaxes and causes the corpora cavernosa to vasodilate. All these effects are mediated by cyclic guanosine monophosphate (cGMP). The inhibition of PDE-5 results in prolonging the effects of cGMP with a subsequent increase in the nitric oxide concentrations. All three PDE5 inhibitors share this common mechanism of action and are only pharmacologically active when cGMP synthesis is activated. The action of the PDE5 inhibitors therefore requires sexual arousal.

Oral PDE-5 inhibitors have reduced rates of adverse events. Although, vardenafil, tadalafil, and sildenafil improve erectile function equally well, the duration of action of the three agents is significantly different. Sildenafil and vardenafil have half-lives of approximately 4 hours, while tadalafil has a half-life of 17.5 hours. In addition, the molecular structural differences are reflected in the pharmacokinetic properties of tadalafil and its selectivity for PDE isozymes.

Cialis as Impotence Medicine

Sexual problems and male impotence can be a thing of the past with the intervention of a wonderful drug called Cialis. Cialis is in a class of medications known as PDE-5 inhibitors, which are used to treat cases of male impotence around the world.

Cialis acts in the same way as other ED drugs by blocking an enzyme called phosphodiesterase-5. It results in fewer sides effects and is taken in lower dosages. Cialis helps the smooth muscles in the penis relax and widen, which allows for more blood to enter, resulting in faster and easier erections.

Cialis is an approved prescription medication for the treatment of mild to severe ED at both 10 and 20mg doses. It should be taken prior to anticipated sexual activity and without regard to food but sexual stimulation is needed for it to work.

Cialis is not for everyone. Men on nitrate drugs and "alpha blockers" should never take Cialis, as these drugs when combined with Cialis may cause blood pressure to drop to unsafe levels.

Benefits of Cialis over other Impotence Medicines

Cialis takes you beyond the world of impotence drugs. It is perhaps the only ED drug that shows definite benefits over other oral ED drugs. Cialis:

·        Works up to 36 hours so sexual activity can be conducted in a relaxed atmosphere and at a leisurely pace

·        Cialis can be administered without regard to food while other ED drugs have dosing restrictions after a high-fat meal

·        Cialis has a different chemical structure while the other two ED drugs have a similar molecular structure

·        Works quickly in as little as 30 minutes in some men

·        Works effectively in mild, moderate, and severe ED conditions

·        Can be taken on an empty stomach therefore it does not need to be planned around meals

·        Lets you choose the right moment that’s suited to you and your partner as it has a 36-hour window

·        Is used by millions of men all over the world

Availability of Cialis

Cialis is now broadly available by prescription in pharmacies in Europe and the United States. It is approved in these markets for the treatment of mild to severe ED at both 10 and 20mg doses. The labels in each of these markets indicate that the product should be taken prior to anticipated sexual activity and without regard to food. Sexual stimulation is needed for Cialis to work. According to the European label, the efficacy of Cialis may persist from up to 24 hours to 36 hours after the pill is taken.

The availability of Cialis has never been a problem. All one needs is a proper prescription from a qualified medical physician. This is vital because over-the-counter sale and purchase of prescribed drugs is considered illegal. In addition, one can also explore availability on online pharmacies so that Cialis can be bought online. Online Cialis can be bought at a fraction of the cost of the drug available offline.

Buying Cialis online is quite simple as it is both cost and time effective and saves on energy, as men do not have to queue in before pharmacies that sell Cialis. All you need to do is fill in a prescription form citing all the details of your medical history. Based on these details, a doctor will decide your eligibility for Cialis intake. What is more, it even gets delivered to your doorstep in a discreet packing.